Natural Antisense Transcripts (NATs) are RNAs that are at least partially complementary to other endogenous RNAs. They might be transcribed in cis from opposing DNA strands at the same genomic locus or in trans at separate loci. NATs have already been found to function at several levels of eukaryotic gene regulation including translational regulation, alternative splicing, RNA stability, trafficking, genomic imprinting, and X-inactivation. Changes in antisense transcription have been implicated in pathogenesis such as cancer or neurological disease.
This release was generated based on UniGene and GoldenPath of Jul., 2006. The previous release of Jul.,2005 was still accessible at http://nats.cbi.pku.edu.cn
Updates:2009-June  Cis-sense/antisense pair cluster infomation including overlapping pattern and coding potentail could be downloaded here2008-July  We identified trans-natural antisense pairs in 10 species recently. You could browse and search in Trans-SAMap. Trans-SAMap is complementary to our NATsDB.2007-Jan   Isoforms predicted by SVAP (Splicing Variant Analysis Platform) have been added into NatsDB as a supporting track. An example is Xist/Tsix genomic locus of Mouse. Users interested in alternative splicing could search isoforms using search modules of NatsDB.
Citation:Li, J.T., Zhang, Y., Kong, L., Liu, Q.R. and Wei, L. (2008) Trans-natural antisense transcripts including noncoding RNAs in 10 species: implications for expression regulation. Nucleic Acids Res.,2008 Sep;36(15):4833-44. Yong Zhang, XS Liu, Qing-Rong Liu and Liping Wei. Genome-wide in
silico identification and analysis of cis-natural antisense
transcripts (cis-NATs) in ten species. Nucleic Acids Res.,
34: 3465-3475Yong Zhang, Jiong-Tang Li, Lei Kong, Ge Gao, Qing-Rong Liu and Liping Wei. (2007) NATsDB:
Natural Antisense Transcripts DataBase. Nucleic Acids Res., 35(Database issue):D156-61