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Natural Antisense Transcripts (NATs) are RNAs that are at least partially complementary to other endogenous RNAs. They might be transcribed in cis from opposing DNA strands at the same genomic locus or in trans at separate loci. NATs have already been found to function at several levels of eukaryotic gene regulation including translational regulation, alternative splicing, RNA stability, trafficking, genomic imprinting, and X-inactivation. Changes in antisense transcription have been implicated in pathogenesis such as cancer or neurological disease.

This release was generated based on UniGene and GoldenPath of Jul., 2006. The previous release of Jul.,2005 was still accessible at http://nats.cbi.pku.edu.cn

Updates: Isoforms predicted by SVAP (Splicing Variant Analysis Platform) have been added into NatsDB as a supporting track. An example is Xist/Tsix genomic locus of Mouse. Users interested in alternative splicing could search isoforms using search modules of NatsDB.

Citation:

  • Yong Zhang, XS Liu, Qing-Rong Liu and Liping Wei. Genome-wide in silico identification and analysis of cis-natural antisense transcripts (cis-NATs) in ten species. Nucleic Acids Res., 34: 3465-3475
  • Yong Zhang, Jiong-Tang Li, Lei Kong, Ge Gao, Qing-Rong Liu and Liping Wei. NATsDB: Natural Antisense Transcripts DataBase. Nucleic Acids Res., in print

    •  Last modified November 14 2006 02:02:04 PM © Center for Bioinformatics, Peking University